Diisopropylethylamine → HCID 19024728, 화합물

HRID 249180노트

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HRID 249180 반응식
[CH2:1]([NH:8][C:9]1[CH:10]=[C:11]([CH:36]=[CH:37][CH:38]=1)[C:12]([C:14]1[C:22]2[C:17](=[CH:18][CH:19]=[CH:20][CH:21]=2)[N:16]([CH2:23][CH2:24][CH2:25][C:26]([O:28][CH2:29][C:30]2[CH:35]=[CH:34][CH:33]=[CH:32][CH:31]=2)=[O:27])[CH:15]=1)=O)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.C(N(C(C)C)CC)(C)C.Br[CH:49]([C:52]1[CH:57]=[CH:56][C:55]([CH2:58][CH:59]([CH3:61])[CH3:60])=[CH:54][CH:53]=1)[CH2:50][CH3:51]>ClCCl>[CH2:1]([N:8]([C:9]1[CH:10]=[C:11]([CH:36]=[CH:37][CH:38]=1)[CH2:12][C:14]1[C:22]2[C:17](=[CH:18][CH:19]=[CH:20][CH:21]=2)[N:16]([CH2:23][CH2:24][CH2:25][C:26]([O:28][CH2:29][C:30]2[CH:35]=[CH:34][CH:33]=[CH:32][CH:31]=2)=[O:27])[CH:15]=1)[CH:49]([C:52]1[CH:53]=[CH:54][C:55]([CH2:58][CH:59]([CH3:60])[CH3:61])=[CH:56][CH:57]=1)[CH2:50][CH3:51])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

참가 물질

5

반응물 3

HCID 81531DiisopropylethylamineHCID 10956141Benzene, 1-(1-bromopropyl)-4-(2-methylpropyl)-HCID 19024820Benzyl 4-[3-(3-benzylaminobenzoyl)indol-1-yl]butyrate

생성물 1

HCID 19024728HCID 19024728, 화합물수율 25.8%

시약·촉매·용매 1

HCID 6344Dichloromethane용매2회

실험 절차

To a solution of benzyl 4-[3-(3-benzylaminobenzoyl)indol-1-yl]butyrate (88 mg) and diisopropylethylamine (45 mg) in dichloromethane (3 ml) was added a solution of 1-bromo-1-(4-isobutylphenyl)propane (90 mg) in dichloromethane (1 ml). The mixture was stirred at room temperature for 24 hours and evaporated. The residue was dissolved in ethyl acetate. The solution was washed with water, dried over magnesium sulfate and evaporated. The residue was chromatographed on silica gel (5 g) eluting with a mixture of n-hexane and ethyl acetate (4:1) to give benzyl 4-[3-[3-[N-benzyl-N-[1-(4-isobutylphenyl)propyl]amino]benzyl]indol-1-yl]butyrate (30 mg) as an oil.

후처리

  1. customevaporated
  2. dissolutionThe residue was dissolved in ethyl acetate
  3. washThe solution was washed with water
  4. dry with materialdried over magnesium sulfate
  5. customevaporated
  6. customThe residue was chromatographed on silica gel (5 g)
  7. washeluting with a mixture of n-hexane and ethyl acetate (4:1)

출처 및 근거

ORD 기록
ord-fe81d29440864b2a9bef95d9541633be
출처 데이터셋
uspto-grants-1993_05
특허 번호
US05212320

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