Hydrochloric Acid → N-methyl-4-nitrophenethylamine

HRID 24920

반응식

HRID 24920 반응식
[CH3:1][NH2:2].Br[CH2:4][CH2:5][C:6]1[CH:11]=[CH:10][C:9]([N+:12]([O-:14])=[O:13])=[CH:8][CH:7]=1.Cl>ClCCl.O>[CH3:1][NH:2][CH2:4][CH2:5][C:6]1[CH:11]=[CH:10][C:9]([N+:12]([O-:14])=[O:13])=[CH:8][CH:7]=1

참가 물질

6

반응물 3

HCID 313Hydrochloric AcidHCID 6329MethylamineHCID 792664-Nitrophenethyl bromide

생성물 1

HCID 2794239N-methyl-4-nitrophenethylamine

시약·촉매·용매 2

HCID 962Water용매HCID 6344Dichloromethane용매

실험 절차

2.7 g (86 mmol) of methylamine are dissolved in 120 ml of dichloromethane while cooling with ice. 4.9 g (21 mmol) of 4-(2-bromoethyl)-nitrobenzene are added and the mixture is allowed to come up slowly to ambient temperature. After 15 hours stirring the solvent is eliminated in vacuo and the residue taken up in water. An acid pH is created using 2 N hydrochloric acid and the mixture is washed with dichloromethane. The aqueous phase is then adjusted to a basic pH using 4 N sodium hydroxide solution and the product is extracted with dichloromethane.

후처리

  1. temperaturewhile cooling with ice
  2. customto come up slowly to ambient temperature
  3. washthe mixture is washed with dichloromethane
  4. extractionthe product is extracted with dichloromethane

출처 및 근거

ORD 기록
ord-0770d44e24ec4c24a921ae9eccf562c9
출처 데이터셋
uspto-grants-2005_02
특허 번호
US06855710B2

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