Hydrochloric Acid → N-methyl-4-nitrophenethylamine
반응식
[CH3:1][NH2:2].Br[CH2:4][CH2:5][C:6]1[CH:11]=[CH:10][C:9]([N+:12]([O-:14])=[O:13])=[CH:8][CH:7]=1.Cl>ClCCl.O>[CH3:1][NH:2][CH2:4][CH2:5][C:6]1[CH:11]=[CH:10][C:9]([N+:12]([O-:14])=[O:13])=[CH:8][CH:7]=1참가 물질
6
실험 절차
2.7 g (86 mmol) of methylamine are dissolved in 120 ml of dichloromethane while cooling with ice. 4.9 g (21 mmol) of 4-(2-bromoethyl)-nitrobenzene are added and the mixture is allowed to come up slowly to ambient temperature. After 15 hours stirring the solvent is eliminated in vacuo and the residue taken up in water. An acid pH is created using 2 N hydrochloric acid and the mixture is washed with dichloromethane. The aqueous phase is then adjusted to a basic pH using 4 N sodium hydroxide solution and the product is extracted with dichloromethane.
후처리
- temperaturewhile cooling with ice
- customto come up slowly to ambient temperature
- washthe mixture is washed with dichloromethane
- extractionthe product is extracted with dichloromethane
출처 및 근거
- ORD 기록
- ord-0770d44e24ec4c24a921ae9eccf562c9
- 출처 데이터셋
- uspto-grants-2005_02
- 특허 번호
- US06855710B2
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