Dimethylformamide → 2-{4-[(3,5-Dichloropyridin-2-yl)oxy]phenoxy}propanoyl chloride

HRID 249200노트

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HRID 249200 반응식
S(Cl)([Cl:3])=O.[Cl:5][C:6]1[C:7]([O:13][C:14]2[CH:25]=[CH:24][C:17]([O:18][CH:19]([CH3:23])[C:20](O)=[O:21])=[CH:16][CH:15]=2)=[N:8][CH:9]=[C:10]([Cl:12])[CH:11]=1.CN(C)C=O>C(Cl)(Cl)Cl>[Cl:5][C:6]1[C:7]([O:13][C:14]2[CH:25]=[CH:24][C:17]([O:18][CH:19]([CH3:23])[C:20]([Cl:3])=[O:21])=[CH:16][CH:15]=2)=[N:8][CH:9]=[C:10]([Cl:12])[CH:11]=1

참가 물질

5

반응물 3

HCID 6228DimethylformamideHCID 24386Thionyl ChlorideHCID 173715Chlorazifop

생성물 1

HCID 131894782-{4-[(3,5-Dichloropyridin-2-yl)oxy]phenoxy}propanoyl chloride

시약·촉매·용매 1

HCID 6212Chloroform용매

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온도
63 °C

실험 절차

Thionyl chloride (18.8 mL, 257.1 mmol) is added dropwise to a mixture of 2-{p-[(3,5-dichloro-2-pyridyl)oxy]phenoxy}propionic acid (21.1 g, 64.3 mmol) in chloroform (220 mL). When the addition is complete, dimethylformamide (1.5 mL) is added and the reaction mixture is stirred for 21 hours at 63° C., concentrated in vacuo and chased with chloroform to obtain the title product as a yellow syrup which is identified by 1H NMR spectral analysis.

후처리

  1. additionWhen the addition
  2. concentrationconcentrated in vacuo and chased with chloroform

출처 및 근거

ORD 기록
ord-9c29c95b3e804780a4b286297116dea5
출처 데이터셋
uspto-grants-1993_05
특허 번호
US05213606

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