Benzyl Chloride → HCID 2845263, 화합물

HRID 249350노트

반응식

HRID 249350 반응식
[C:1]([N:4]1[CH2:9][CH2:8][CH:7]([NH:10][CH3:11])[CH2:6][CH2:5]1)(=[O:3])[CH3:2].[CH2:12](Cl)[C:13]1[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=1.C(=O)([O-])[O-].[Na+].[Na+]>C(O)C>[C:1]([N:4]1[CH2:9][CH2:8][CH:7]([NH:10][CH2:11][CH2:12][C:13]2[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=2)[CH2:6][CH2:5]1)(=[O:3])[CH3:2]

참가 물질

5

반응물 3

HCID 7503Benzyl ChlorideHCID 10340Sodium CarbonateHCID 197612651-[4-(Methylamino)piperidin-1-yl]ethan-1-one

생성물 1

HCID 2845263HCID 2845263, 화합물수율 65%

시약·촉매·용매 1

HCID 702Ethanol용매

실험 절차

A mixture containing 0.5 mol of the compound obtained in Stage A of Example 19, 0.5M benzyl chloride and 1M sodium carbonate in 650 ml of ethanol is refluxed for one night. The precipitate formed is filtered off, the solvent is evaporated, the evaporation residue is taken up in 1N hydrochloric acid and extracted with diethyl ether, and the ethereal extract is rendered basic with sodium hydroxide solution and extracted with ethyl acetate to obtain the desired compound.

후처리

  1. temperatureis refluxed for one night
  2. customThe precipitate formed
  3. filtrationis filtered off
  4. customthe solvent is evaporated
  5. extractionextracted with diethyl ether
  6. extractionthe ethereal extract
  7. extractionextracted with ethyl acetate

출처 및 근거

ORD 기록
ord-80149424651e4c6585a15e7b982377e3
출처 데이터셋
uspto-grants-1993_05
특허 번호
US05214055

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