2-Propanesulfonyl chloride → Isopropylsulphonic acid-(4-tert.butoxycarbonylamino-phenyl)-amide

HRID 24939

반응식

HRID 24939 반응식
[CH:1]([S:4](Cl)(=[O:6])=[O:5])([CH3:3])[CH3:2].[C:8]([O:12][C:13]([NH:15][C:16]1[CH:22]=[CH:21][C:19]([NH2:20])=[CH:18][CH:17]=1)=[O:14])([CH3:11])([CH3:10])[CH3:9]>N1C=CC=CC=1>[C:8]([O:12][C:13]([NH:15][C:16]1[CH:17]=[CH:18][C:19]([NH:20][S:4]([CH:1]([CH3:3])[CH3:2])(=[O:6])=[O:5])=[CH:21][CH:22]=1)=[O:14])([CH3:11])([CH3:9])[CH3:10]

참가 물질

4

반응물 2

HCID 824082-Propanesulfonyl chlorideHCID 688611tert-Butyl (4-aminophenyl)carbamate

생성물 1

HCID 22569426Isopropylsulphonic acid-(4-tert.butoxycarbonylamino-phenyl)-amide

시약·촉매·용매 1

HCID 1049Pyridine용매

실험 절차

1.2 g (10 mmol) of isopropylsulphonic acid chloride are added dropwise to a solution of 1.0 g (4.8 mmol) of 4-tert.butoxycarbonylamino-aniline in 10 ml of pyridine. The mixture is stirred for 18 hours at ambient temperature. Then the reaction solution is poured onto 150 ml of ice water and then extracted with ethyl acetate. The organic phases are washed with water and freed from solvent. The residue is chromatographed on silica gel (dichloromethane/methanol/NH4OH=19:1:0.1).

후처리

  1. extractionextracted with ethyl acetate
  2. washThe organic phases are washed with water
  3. customThe residue is chromatographed on silica gel (dichloromethane/methanol/NH4OH=19:1:0.1)

출처 및 근거

ORD 기록
ord-da9825c092654534b8c9572e9d0b2491
출처 데이터셋
uspto-grants-2005_02
특허 번호
US06855710B2

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