Formic Acid → 4-(n-(2-Dimethylaminoethyl)-n-formyl-amino)-nitrobenzene

HRID 24944노트

반응식

HRID 24944 반응식
[CH3:1][N:2]([CH3:15])[CH2:3][CH2:4][NH:5][C:6]1[CH:11]=[CH:10][C:9]([N+:12]([O-:14])=[O:13])=[CH:8][CH:7]=1.[OH-].[Na+].[CH:18](O)=[O:19]>O>[CH3:1][N:2]([CH3:15])[CH2:3][CH2:4][N:5]([C:6]1[CH:11]=[CH:10][C:9]([N+:12]([O-:14])=[O:13])=[CH:8][CH:7]=1)[CH:18]=[O:19]

참가 물질

5

반응물 3

HCID 284Formic AcidHCID 14798Sodium HydroxideHCID 22569398HCID 22569398, 화합물

생성물 1

HCID 225694284-(n-(2-Dimethylaminoethyl)-n-formyl-amino)-nitrobenzene

시약·촉매·용매 1

HCID 962Water용매

실험 절차

1.4 g (6.7 mmol) of 4-(2-dimethylamino-ethylamino)-nitrobenzene (Example 326a) are refluxed for 4 hours in 20 ml of formic acid. Then the solvent is eliminated in vacuo, the residue taken up in water and combined with 2 N sodium hydroxide solution until an alkaline reaction is obtained. The mixture is extracted with ethyl acetate, the combined organic phases are dried over magnesium sulphate and the solvent is eliminated in vacuo. The product is obtained as an oil.

후처리

  1. customis obtained
  2. extractionThe mixture is extracted with ethyl acetate
  3. dry with materialthe combined organic phases are dried over magnesium sulphate
  4. customThe product is obtained as an oil

출처 및 근거

ORD 기록
ord-14638ac4203a46dda21480f2af6d163b
출처 데이터셋
uspto-grants-2005_02
특허 번호
US06855710B2

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