Thionyl Chloride → Pyridine, 3-(2-chloroethyl)-, hydrochloride

HRID 249477

반응식

HRID 249477 반응식
[N:1]1[CH:6]=[CH:5][CH:4]=[C:3]([CH2:7][CH2:8]O)[CH:2]=1.S(Cl)([Cl:12])=O>C(Cl)(Cl)Cl>[ClH:12].[N:1]1[CH:6]=[CH:5][CH:4]=[C:3]([CH2:7][CH2:8][Cl:12])[CH:2]=1

참가 물질

4

반응물 2

HCID 24386Thionyl ChlorideHCID 805153-Pyridineethanol

생성물 1

HCID 199465Pyridine, 3-(2-chloroethyl)-, hydrochloride

시약·촉매·용매 1

HCID 6212Chloroform용매

실험 절차

In 100 ml of CHCl3 was dissolved 6.39 g (0.052 mole) of 2-(3-pyridyl)ethanol followed by dropwise addition of 15.6 ml of thionyl chloride with stirring at room temperature. Then, the mixture was stirred for 1.5 hours, after which the solvent was distilled off. After addition of ether, crystals were recovered by filtration and dried. The procedure gave 9.13 g of 2-(3-pyridyl)ethyl chloride hydrochloride as white crystals.

후처리

  1. stirringThen, the mixture was stirred for 1.5 hours
  2. distillationafter which the solvent was distilled off
  3. additionAfter addition of ether, crystals
  4. filtrationwere recovered by filtration
  5. customdried

출처 및 근거

ORD 기록
ord-450f1aa5091b42bdb483c6d772a4818a
출처 데이터셋
uspto-grants-1993_05
특허 번호
US05214152

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