Dimethylformamide → 2-Phenylbutyryl chloride

HRID 249537

반응식

HRID 249537 반응식
S(Cl)([Cl:3])=O.[C:5]1([CH:11]([CH2:15][CH3:16])[C:12](O)=[O:13])[CH:10]=[CH:9][CH:8]=[CH:7][CH:6]=1.CN(C=O)C>C(Cl)Cl>[C:5]1([CH:11]([CH2:15][CH3:16])[C:12]([Cl:3])=[O:13])[CH:10]=[CH:9][CH:8]=[CH:7][CH:6]=1

참가 물질

5

반응물 3

HCID 6228DimethylformamideHCID 70122-Phenylbutyric AcidHCID 24386Thionyl Chloride

생성물 1

HCID 981732-Phenylbutyryl chloride수율 68%

시약·촉매·용매 1

HCID 6344Dichloromethane용매

실험 절차

Thionyl chloride (0.12 mol) in 60 mL of CH2Cl2 was added to a stirred solution of 2-phenylbutyric acid (16.4 g, 0.10 mol). A catalytic amount of DMF was added and the reaction was allowed to continue overnight at room temperature. The volatiles were removed under vacuum and the residual liquid was vacuum distilled to yield 12.4 g (68%) of 2-phenylbutyryl chloride. IR (neat) 1798 cm-1 (C=O).

후처리

  1. customThe volatiles were removed under vacuum
  2. distillationdistilled

출처 및 근거

ORD 기록
ord-27d8209bcb5d425b9dd1ab8a3f96bc9c
출처 데이터셋
uspto-grants-1993_05
특허 번호
US05214191

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