1,2-Bis(2-(tert-butyloxycarbonyl)aminooxyethoxy)ethane → Bis-aminooxy-PEG2

HRID 24957노트

반응식

HRID 24957 반응식
C(OC([NH:8][O:9][CH2:10][CH2:11][O:12][CH2:13][CH2:14][O:15][CH2:16][CH2:17][O:18][NH:19]C(OC(C)(C)C)=O)=O)(C)(C)C>CCOC(C)=O.Cl>[NH2:19][O:18][CH2:17][CH2:16][O:15][CH2:14][CH2:13][O:12][CH2:11][CH2:10][O:9][NH2:8]

참가 물질

4

반응물 1

HCID 110362781,2-Bis(2-(tert-butyloxycarbonyl)aminooxyethoxy)ethane

생성물 1

HCID 3306142Bis-aminooxy-PEG2수율 90%

시약·촉매·용매 2

HCID 313Hydrochloric Acid용매HCID 8857Ethyl Acetate용매

실험 절차

Compound 36 (559 mg, 1.47 mmol) was dissolved in 15 mL of of EtOAc, and HCl gas was bubbled through the solution for 30 minutes. The mixture was concentrated under vacuum to provide 72 mg (90%) of compound 37 as the HCl salt as a sticky residue: 1H NMR (D2O) δ 3.75 (s, 4H), 3.87 (m, 4H), 4.27 (m, 4H); mass spectrum (ES) m/z calculated for C6H17N2O4 (M+H): 181.1. Found: 181.1.

후처리

  1. customwas bubbled through the solution for 30 minutes
  2. concentrationThe mixture was concentrated under vacuum

출처 및 근거

ORD 기록
ord-c48368b2745445a4aaf4c31711b1143d
출처 데이터셋
uspto-grants-2005_02
특허 번호
US06858210B1

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