2-Acetylpyridine → 3-Dimethylamino-1-(2-pyridyl)prop-2-en-1-one

반응식

[C:1]([C:4]1[CH:9]=[CH:8][CH:7]=[CH:6][N:5]=1)(=[O:3])[CH3:2].CO[CH:12](OC)[N:13]([CH3:15])[CH3:14]>>[N:5]1[CH:6]=[CH:7][CH:8]=[CH:9][C:4]=1[C:1](=[O:3])[CH:2]=[CH:12][N:13]([CH3:15])[CH3:14]

참가 물질

반응물 2

HCID 142862-Acetylpyridine

HCID 78373Dimethylformamide dimethyl acetal

생성물 1

HCID 5669933-Dimethylamino-1-(2-pyridyl)prop-2-en-1-one수율 83.7%

반응 조건

온도: 104 °C

실험 절차

2-Acetylpyridine (48.28 g, 0.398 mole) and N,N-Dimethylformamide dimethyl acetal (95 g. 0.797 mole) were added to a flask. The reaction mixture was heated to 104° C. for 15 hours. The excess N,N-Dimethylformamide dimethyl acetal was evaporated off. The residue was recrystallized from a mixture of toluene (140 mL.) and heptane (955 mL.) to give 1-(2-pyridyl)-3-dimethylamino-2-propen-1-one (58.7 g, 70% yield).

후처리

customThe excess N,N-Dimethylformamide dimethyl acetal was evaporated off
customThe residue was recrystallized from a mixture of toluene (140 mL.) and heptane (955 mL.)

출처 및 근거

ORD 기록: ord-03c12c32833a4d7faa592f0a792a4b74
출처 데이터셋: uspto-grants-2005_02
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US06858327B2

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