Sodium Hydroxide → 6-(3-Benzyloxycarbonylaminopropionylamino)-hexanoic acid

HRID 249629노트

반응식

HRID 249629 반응식
C[O:2][C:3](=[O:25])[CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][NH:9][C:10](=[O:24])[CH2:11][CH2:12][NH:13][C:14]([O:16][CH2:17][C:18]1[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=1)=[O:15].[OH-].[Na+]>CO>[CH2:17]([O:16][C:14]([NH:13][CH2:12][CH2:11][C:10]([NH:9][CH2:8][CH2:7][CH2:6][CH2:5][CH2:4][C:3]([OH:25])=[O:2])=[O:24])=[O:15])[C:18]1[CH:19]=[CH:20][CH:21]=[CH:22][CH:23]=1

참가 물질

4

반응물 2

HCID 14798Sodium HydroxideHCID 692961146-(3-Benzyloxycarbonylaminopropionylamino)-hexanoic acid methyl ester

생성물 1

HCID 692965966-(3-Benzyloxycarbonylaminopropionylamino)-hexanoic acid

시약·촉매·용매 1

HCID 887Methanol용매

실험 절차

The compound 36 was prepared using General Procedure A with ester 35 (3.20 g, 9.13 mmol) and an aqueous NaOH solution (1.46 g, 36.53 mmol in 40 mL of H2O) in MeOH (40 mL). Recrystallization from MeOH produced the desired acid 36 in 95% (2.92 g) yield as a white solid. 1H NMR (CDCl3): δ 7.32 (m, 5H, ArH), 6.10 (s, 1H, NH), 5.67 (s, 1H, NH), 5.04 (s, 2H, OCH2Ar), 3.45 (dt, J=6.4, 12.0 Hz, 2H, CH2NHCO), 3.21 (dt, J=6.4, 12.8 Hz, 2H, CH2NHCO), 2.40 (dt, J=6.0, 6.4 Hz, 2H, CH2CO), 2.32 (t, J=7.2 Hz, 2H, CH2CO), 1.61 (m, 2H, CH2), 1.48 (m, 2H, CH2), 1.33 (m, 2H, CH2); ESI-MS m/z 371[M+Cl]−, 359[M+Na]+, 337[M+H]+, 335[M−H]−.

후처리

  1. customThe compound 36 was prepared
  2. customRecrystallization from MeOH

출처 및 근거

ORD 기록
ord-54d682a6b1bc444dbeb90db8e1f94eb9
출처 데이터셋
uspto-grants-2011_01
특허 번호
US07862807B2

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