Ethyl Acetoacetate → HCID 178429414, 화합물

HRID 24963

반응식

HRID 24963 반응식
C(=O)(O)O.[NH2:5][C:6]([NH2:8])=[NH:7].[C:9](OCC)(=[O:14])[CH2:10][C:11]([CH3:13])=O>C(O)C>[CH3:13][C:11]1[NH:5][C:6]([NH2:8])=[N:7][C:9](=[O:14])[CH:10]=1

참가 물질

4

반응물 2

HCID 8868Ethyl AcetoacetateHCID 286947Carbonic acid-guanidine (1:1)

생성물 1

HCID 178429414HCID 178429414, 화합물수율 125.6%

시약·촉매·용매 1

HCID 702Ethanol용매

실험 절차

Dry ethanol (600 mL), 91.89 g of guanidine carbonate, and 146.1 g of ethyl acetoacetate were added to a 1 L flask. The reaction solution was gradually heated to reflux temperature and stirred overnight. Ethanol (300 mL) was evaporated, and the reaction mixture was heated under reflux for two hours. After the reaction mixture was cooled, 300 mL of hexane was added. The resulting precipitate was filtered, washed and dried. 119.3 g of 6-methyl-iso cytosine was obtained.

후처리

  1. temperatureThe reaction solution was gradually heated
  2. temperatureto reflux temperature
  3. customEthanol (300 mL) was evaporated
  4. temperaturethe reaction mixture was heated
  5. temperatureunder reflux for two hours
  6. temperatureAfter the reaction mixture was cooled
  7. addition300 mL of hexane was added
  8. filtrationThe resulting precipitate was filtered
  9. washwashed
  10. customdried

출처 및 근거

ORD 기록
ord-d0a2792311094e53ba927cdb4a416d7a
출처 데이터셋
uspto-grants-2005_02
특허 번호
US06858359B2

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