Ethyl 4-Chloroquinoline-3-carboxylate → Ethyl 4-chloro-6-fluoroquinoline-3-carboxylate

HRID 249673

반응식

HRID 249673 반응식
[Cl:1][C:2]1[C:11]2[C:6](=[CH:7][CH:8]=[CH:9][CH:10]=2)[N:5]=[CH:4][C:3]=1[C:12]([O:14][CH2:15][CH3:16])=[O:13].[F:17]C1C=C2C(=CC=1)N=CC(C(OCC)=O)=C2O>>[Cl:1][C:2]1[C:11]2[C:6](=[CH:7][CH:8]=[C:9]([F:17])[CH:10]=2)[N:5]=[CH:4][C:3]=1[C:12]([O:14][CH2:15][CH3:16])=[O:13]

참가 물질

3

반응물 2

HCID 268963Ethyl 4-Chloroquinoline-3-carboxylateHCID 178469553HCID 178469553, 화합물

생성물 1

HCID 1479088Ethyl 4-chloro-6-fluoroquinoline-3-carboxylate

실험 절차

The title compound was prepared following the procedure described in Step 2 for the synthesis of 3a using 2b instead of 2a. 1H NMR (CDCl3) δ (ppm): 1.47 (3H, t, J=7.08 Hz), 4.51 (2H, q, J=7.08 Hz), 7.63 (1H, m), 8.02 (1H, dd, J=9.52, 2.68 Hz), 8.15 (1H, dd, J=9.27, 5.37 Hz), 9.15 (1H, s). m/z 254.6 (MH+).

출처 및 근거

ORD 기록
ord-d4f34c16031c47b7b516f9ebb1546ff4
출처 데이터셋
uspto-grants-2011_01
특허 번호
US07863266B2

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