Tetrahydrothiophene → 1-(3,3-Dimethyl-2-oxobutyl)thiolan-1-ium bromide

HRID 24968

반응식

HRID 24968 반응식
[S:1]1[CH2:5][CH2:4][CH2:3][CH2:2]1.[Br:6][CH2:7][C:8](=[O:13])[C:9]([CH3:12])([CH3:11])[CH3:10]>C(#N)C>[Br-:6].[O:13]=[C:8]([C:9]([CH3:12])([CH3:11])[CH3:10])[CH2:7][S+:1]1[CH2:5][CH2:4][CH2:3][CH2:2]1

참가 물질

4

반응물 2

HCID 1127TetrahydrothiopheneHCID 21642Bromopinacolone

생성물 1

HCID 225645781-(3,3-Dimethyl-2-oxobutyl)thiolan-1-ium bromide수율 80.4%

시약·촉매·용매 1

HCID 6342Acetonitrile용매

실험 절차

Tetrahydrothiophene (11.8 g) was dissolved in 100 ml of acetonitrile, and 20 g of 1-bromo-3,3-dimethyl-2-butanone was slowly added to the above solution. The reaction solution was stirred at room temperature for two days, thereby a powder was precipitated. After adding 100 ml of ethyl acetate to the reaction solution, the powder was filtered out, washed with ethyl acetate and dried, thereby 24 g of 2-oxo-3,3-dimethylbutyltetrahydrothiophenium bromide was obtained.

후처리

  1. customa powder was precipitated
  2. additionAfter adding 100 ml of ethyl acetate to the reaction solution
  3. filtrationthe powder was filtered out
  4. washwashed with ethyl acetate
  5. customdried

출처 및 근거

ORD 기록
ord-11e4aee2f6d84e11a6513bca5d39247a
출처 데이터셋
uspto-grants-2005_02
특허 번호
US06858370B2

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