Methyl iodide → Ethyl 2-methoxy-6-methylisonicotinate

HRID 249731노트

반응식

HRID 249731 반응식
[OH:1][C:2]1[CH:3]=[C:4]([CH:10]=[C:11]([CH3:13])[N:12]=1)[C:5]([O:7][CH2:8][CH3:9])=[O:6].[CH3:14]I>C1(C)C=CC=CC=1>[CH3:14][O:1][C:2]1[CH:3]=[C:4]([CH:10]=[C:11]([CH3:13])[N:12]=1)[C:5]([O:7][CH2:8][CH3:9])=[O:6]

참가 물질

4

반응물 2

HCID 6328Methyl iodideHCID 178469038HCID 178469038, 화합물

생성물 1

HCID 45076200Ethyl 2-methoxy-6-methylisonicotinate수율 77.7%

시약·촉매·용매 1

HCID 1140Toluene용매

반응 조건

온도
100 °C

실험 절차

20.0 g (111.4 mmol) of ethyl 2-hydroxy-6-methylisonicotinate (20a) were suspended in 330 ml of toluene. After addition of 36.54 g (132.5 mmol) of Ag2CO3 and 23.5 g (165.6 mmol) of methyl iodide, the mixture was heated to 100° C. with KPG stirring. After 4 hours, the reaction mixture was allowed to cool to RT and it was filtered through Celite. The filtrate was washed twice with water, dried with Na2SO4 and concentrated, 16.9 g of the title compound being isolated as a yellowish oil.

후처리

  1. temperatureto cool to RT
  2. filtrationit was filtered through Celite
  3. washThe filtrate was washed twice with water
  4. dry with materialdried with Na2SO4
  5. concentrationconcentrated

출처 및 근거

ORD 기록
ord-fda1b12a7fe14a0dbd517374718a985e
출처 데이터셋
uspto-grants-2011_01
특허 번호
US07863269B2

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