Hydrazine → Pyrimidine-4-carbohydrazide

HRID 249780

반응식

HRID 249780 반응식
[N:1]1[CH:6]=[CH:5][C:4]([C:7]([OH:9])=O)=[N:3][CH:2]=1.C1N=CN(C(N2C=NC=C2)=O)C=1.[NH2:22][NH2:23]>C1COCC1>[N:1]1[CH:6]=[CH:5][C:4]([C:7]([NH:22][NH2:23])=[O:9])=[N:3][CH:2]=1

참가 물질

5

반응물 3

HCID 9321HydrazineHCID 682631,1'-CarbonyldiimidazoleHCID 1693064-Pyrimidinecarboxylic acid

생성물 1

HCID 468664Pyrimidine-4-carbohydrazide

시약·촉매·용매 1

HCID 8028Tetrahydrofuran용매

실험 절차

To a solution of pyrimidine-4-carboxylic acid (1.0 g, 8.0 mmol) in THF (15 mL), N,N-Carbonyldiimidazole (1.4 g, 8.9 mmol) was added. After refluxing for 2 hours, hydrazine (0.8 g, 20 mmol) was added to the reaction mixture slowly with a syringe at 0° C. The reaction mixture was allowed to warm to room temperature slowly and then concentrated to yield the desired product as white solid. LCMS calculated for C5H7N4O (M+H): 139.1. found: 139.1.

후처리

  1. temperatureAfter refluxing for 2 hours
  2. concentrationconcentrated

출처 및 근거

ORD 기록
ord-295e910fa0114ff3a389fbb08f41978a
출처 데이터셋
uspto-grants-2011_01
특허 번호
US07863285B2

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