Ethyl 3-mercaptopropionate → Ethyl 3-((4-hydroxyphenyl)-methylthio)propionate

HRID 25001

반응식

HRID 25001 반응식
[H-].[Na+].[SH:3][CH2:4][CH2:5][C:6]([O:8][CH2:9][CH3:10])=[O:7].[H][H].[OH:13][C:14]1[CH:21]=[CH:20][C:17]([CH2:18]Br)=[CH:16][CH:15]=1>CN(C=O)C>[OH:13][C:14]1[CH:21]=[CH:20][C:17]([CH2:18][S:3][CH2:4][CH2:5][C:6]([O:8][CH2:9][CH3:10])=[O:7])=[CH:16][CH:15]=1

참가 물질

6

반응물 4

HCID 21625Ethyl 3-mercaptopropionateHCID 24758Sodium hydrideHCID 41663BromocresolHCID 178418361HCID 178418361, 화합물

생성물 1

HCID 21964457Ethyl 3-((4-hydroxyphenyl)-methylthio)propionate

시약·촉매·용매 1

HCID 6228Dimethylformamide용매

실험 절차

To a solution of NaH (60% dispersed in oil, 0.731 g, 21.7 mmol) in dry DMF (15 ml) was added Ethyl 3-mercaptopropionate (2.66 g, 19.8 mmol). When the evolution of hydrogen ceased, 4-Hydroxybenzyl bromide from Step A was added. The reaction mixture was stirred for 16 hours at room temperature, quenched with sat. NH4Cl and concentrated in vacuo. The crude residue was taken in EtOAc and washed with water and brine. The aqueous layer was washed one more time with EtOAc. The combined organic layers were dried over Na2SO4, filtered and concentrated. The purification was done by flash chromatography on silica gel column (dichloromethane: ethyl acetate, 95:5) to provide the title compound.

후처리

  1. customquenched with sat. NH4Cl
  2. concentrationconcentrated in vacuo
  3. washwashed with water and brine
  4. washThe aqueous layer was washed one more time with EtOAc
  5. dry with materialThe combined organic layers were dried over Na2SO4
  6. filtrationfiltered
  7. concentrationconcentrated
  8. customThe purification

출처 및 근거

ORD 기록
ord-81ebd90db5d4451eb87d433aa6422781
출처 데이터셋
uspto-grants-2005_02
특허 번호
US06858602B2

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