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Dimethylformamide → methyl N-(4-cyanophenyl)-N-[4-amino-6-[(2,6-dichlorophenyl)methyl]-1,3,5-triazin-2-yl]glycine

HRID 25051
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HRID 25051 반응식
[H-].[Na+].[NH2:3][C:4]1[N:9]=[C:8]([CH2:10][C:11]2[C:16]([Cl:17])=[CH:15][CH:14]=[CH:13][C:12]=2[Cl:18])[N:7]=[C:6]([NH:19][C:20]2[CH:27]=[CH:26][C:23]([C:24]#[N:25])=[CH:22][CH:21]=2)[N:5]=1.C[O:29][C:30](=[O:33])[CH2:31]Cl.[CH3:34]N(C=O)C>>[CH3:34][CH:31]([C:30]([OH:29])=[O:33])[N:19]([C:20]1[CH:21]=[CH:22][C:23]([C:24]#[N:25])=[CH:26][CH:27]=1)[C:6]1[N:5]=[C:4]([NH2:3])[N:9]=[C:8]([CH2:10][C:11]2[C:16]([Cl:17])=[CH:15][CH:14]=[CH:13][C:12]=2[Cl:18])[N:7]=1
참가 물질반응 조건실험 절차후처리출처 및 근거반응 노트

참가 물질

5

반응물 4

HCID 6228DimethylformamideHCID 7295Methyl chloroacetateHCID 24758Sodium hydrideHCID 4863624-[[4-Amino-6-[(2,6-dichlorophenyl)methyl]-1,3,5-triazin-2-yl]amino]benzonitrile

생성물 1

HCID 22281687methyl N-(4-cyanophenyl)-N-[4-amino-6-[(2,6-dichlorophenyl)methyl]-1,3,5-triazin-2-yl]glycine수율 19.4%

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온도
70 °C

실험 절차

A solution of sodium hydride (0.00195 mol) in DMF (7 ml) was added to compound (1) (0.00186 mol) and the resulting solution was stirred for 5 minutes under argon. Then, chloroacetic acid methyl ester (0.0186 mol) was added and the reaction mixture was heated to 70° C. for 19 hours. The reaction mixture was then quenched with water and the resulting solid was filtered off. The residue was treated with hot ACN, then filtered while still hot. The residue from the cooled filtrate was recrystallized from 1,4-dioxane. The precipitate was filtered off, yielding 0.16 g (19.4%) of methyl N-(4-cyanophenyl)-N-[4-amino-6-[(2,6-dichlorophenyl)methyl]-1,3,5-triazin-2-yl]glycine (compound 39).

후처리

  1. customThe reaction mixture was then quenched with water
  2. filtrationthe resulting solid was filtered off
  3. additionThe residue was treated with hot ACN
  4. filtrationfiltered while still hot
  5. customThe residue from the cooled filtrate was recrystallized from 1,4-dioxane
  6. filtrationThe precipitate was filtered off

출처 및 근거

ORD 기록
ord-aec5bb57d76b45cbac751505cdb98cb7
출처 데이터셋
uspto-grants-2005_02
DOI
10.6084/m9.figshare.5104873.v1
특허 번호
US06858609B2

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