Cyclopentylamine → HCID 86067038, 화합물

HRID 250725노트

반응식

HRID 250725 반응식
[CH3:1][N:2]([O:15][CH3:16])[C:3](=[O:14])[C:4]1[CH:9]=[CH:8][C:7]([N+:10]([O-:12])=[O:11])=[C:6](F)[CH:5]=1.[CH:17]1([NH2:22])[CH2:21][CH2:20][CH2:19][CH2:18]1.C(#N)C>Cl>[CH3:16][O:15][N:2]([CH3:1])[C:3](=[O:14])[C:4]1[CH:9]=[CH:8][C:7]([N+:10]([O-:12])=[O:11])=[C:6]([NH:22][CH:17]2[CH2:21][CH2:20][CH2:19][CH2:18]2)[CH:5]=1

참가 물질

5

반응물 3

HCID 2906CyclopentylamineHCID 6342AcetonitrileHCID 577580833-Fluoro-N-methoxy-N-methyl-4-nitrobenzamide

생성물 1

HCID 86067038HCID 86067038, 화합물수율 92.1%

시약·촉매·용매 1

HCID 313Hydrochloric Acid용매

실험 절차

Combine N-[methyl]N-[methoxy]3-fluoro-4-nitrobenzamide (2.3 g, 10 mmol), cyclopentylamine (12.3 mL, 100 mmol) and acetonitrile (50 mL) and stir at room temperature for 6 hours. Dilute with 1N HCl and extract with ethyl acetate. Wash the organic layer sequentially with water and saturated aqueous sodium chloride, then dry over magnesium sulfate. Concentrate under reduced pressure to provide the desired compound as an orange solid (2.7 g, 92%).

후처리

  1. extractionextract with ethyl acetate
  2. washWash the organic layer sequentially with water and saturated aqueous sodium chloride
  3. dry with materialdry over magnesium sulfate
  4. concentrationConcentrate under reduced pressure

출처 및 근거

ORD 기록
ord-47f792c7a0824ddcb95f086460f770ef
출처 데이터셋
uspto-grants-2011_01
특허 번호
US07863310B2

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