Isopropylamine → 5-Bromo-N-isopropyl-2-nitroaniline
반응식
Br[C:2]1[CH:7]=[C:6]([Br:8])[CH:5]=[CH:4][C:3]=1[N+:9]([O-:11])=[O:10].[CH:12]([NH2:15])([CH3:14])[CH3:13]>C(O)CCC>[CH:12]([NH:15][C:2]1[CH:7]=[C:6]([Br:8])[CH:5]=[CH:4][C:3]=1[N+:9]([O-:11])=[O:10])([CH3:14])[CH3:13]참가 물질
4
실험 절차
Heat a mixture of 2,4-dibromonitrobenzene (3.50 g, 12.5 mmol), isopropylamine (4.42 g, 6.40 ml, 74.8 mmol) and n-butanol (20 ml) in a sealed reaction vessel to 117° C. overnight. Cool to room temperature and concentrate under reduced pressure. Partition the residue between ethyl acetate and saturated aqueous sodium chloride, dry the organic layer over sodium sulfate, and concentrate under reduced pressure to provide the desired compound as a yellow solid (3.0 g, 94%).
후처리
- temperatureHeat
- customin a sealed reaction vessel to 117° C. overnight
- concentrationconcentrate under reduced pressure
- customPartition the residue between ethyl acetate and saturated aqueous sodium chloride
- dry with materialdry the organic layer over sodium sulfate
- concentrationconcentrate under reduced pressure
출처 및 근거
- ORD 기록
- ord-edab10343770457682b580b83bba213f
- 출처 데이터셋
- uspto-grants-2011_01
- 특허 번호
- US07863310B2
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