홈MCP워크벤치Skills
홈워크벤치알림마이페이지
llms.txt · MCP 가이드개인정보처리방침 · 이용약관 · 지원v1.8.0
  1. 홈
  2. /반응

Methanol → (+/-)-8-Methyl-7-(2-methyl-3-oxo-2,3-dihydro-1,2,4-thiadiazol-5-yl)-5-(4-nitrophenyl)-8,9-dihydro-7H-1,3-dioxolo[4,5-h][2,3]benzodiazepine

HRID 25080
노트
인쇄 미리보기

반응식

HRID 25080 반응식
[CH3:1][NH:2][C:3]([NH:5][C:6]([N:8]1[CH:14]([CH3:15])[CH2:13][C:12]2[CH:16]=[C:17]3[O:22][CH2:21][O:20][C:18]3=[CH:19][C:11]=2[C:10]([C:23]2[CH:28]=[CH:27][C:26]([N+:29]([O-:31])=[O:30])=[CH:25][CH:24]=2)=[N:9]1)=[S:7])=[O:4].BrBr.CO>C(Cl)(Cl)Cl>[CH3:15][CH:14]1[CH2:13][C:12]2[CH:16]=[C:17]3[O:22][CH2:21][O:20][C:18]3=[CH:19][C:11]=2[C:10]([C:23]2[CH:28]=[CH:27][C:26]([N+:29]([O-:31])=[O:30])=[CH:25][CH:24]=2)=[N:9][N:8]1[C:6]1[S:7][N:2]([CH3:1])[C:3](=[O:4])[N:5]=1
참가 물질실험 절차후처리출처 및 근거반응 노트

참가 물질

5

반응물 3

HCID 887MethanolHCID 24408BromineHCID 86593814(+/-)-1-Methyl-3-{8-methyl-5-(4-nitrophenyl)-8,9-dihydro-7H-1,3-dioxolo[4,5-h][2,3]benzodiazepine-7-carbothioyl}-urea

생성물 1

HCID 22565496(+/-)-8-Methyl-7-(2-methyl-3-oxo-2,3-dihydro-1,2,4-thiadiazol-5-yl)-5-(4-nitrophenyl)-8,9-dihydro-7H-1,3-dioxolo[4,5-h][2,3]benzodiazepine수율 82%

시약·촉매·용매 1

HCID 6212
Chloroform
용매
3회

실험 절차

To an ice cooled stirred solution of 0.44 g (1.0 mmol) of the starting material XXVII in 8 ml of chloroform a solution of 0.19 g (1.2 mmol) of bromine in 3 ml of chloroform was added. After 0.5 h the reaction mixture was diluted with 15 ml of chloroform and washed with sodium hydrogen carbonate solution and water. The residue obtained on concentration was stirred with methanol and filtered to yield 0.36 g (82%) of the title compound. Mp.: 296° C. after recrystallization from ethyl acetate.

후처리

  1. additionwas added
  2. washwashed with sodium hydrogen carbonate solution and water
  3. customThe residue obtained on concentration
  4. filtrationfiltered

출처 및 근거

ORD 기록
ord-20f6119f8dc742118769727308234a2c
출처 데이터셋
uspto-grants-2005_02
DOI
10.6084/m9.figshare.5104873.v1
특허 번호
US06858605B2

반응 노트

불러오는 중…

이 페이지에서참가 물질실험 절차후처리출처 및 근거반응 노트