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llms.txt · MCP 가이드개인정보처리방침 · 이용약관 · 지원v1.8.0
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Acetic Acid → (+/-)-7-(4-Carboxythiazol-2-yl)-8-methyl-5-(4-nitrophenyl)-8,9-dihydro-7H-1,3-dioxolo[4,5-h][2,3]benzodiazepine

HRID 25081
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인쇄 미리보기

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HRID 25081 반응식
C(O)C.C([O:6][C:7]([C:9]1[N:10]=[C:11]([N:14]2[CH:20]([CH3:21])[CH2:19][C:18]3[CH:22]=[C:23]4[O:28][CH2:27][O:26][C:24]4=[CH:25][C:17]=3[C:16]([C:29]3[CH:34]=[CH:33][C:32]([N+:35]([O-:37])=[O:36])=[CH:31][CH:30]=3)=[N:15]2)[S:12][CH:13]=1)=[O:8])C.[OH-].[Na+].C(O)(=O)C>O>[C:7]([C:9]1[N:10]=[C:11]([N:14]2[CH:20]([CH3:21])[CH2:19][C:18]3[CH:22]=[C:23]4[O:28][CH2:27][O:26][C:24]4=[CH:25][C:17]=3[C:16]([C:29]3[CH:34]=[CH:33][C:32]([N+:35]([O-:37])=[O:36])=[CH:31][CH:30]=3)=[N:15]2)[S:12][CH:13]=1)([OH:8])=[O:6]
참가 물질반응 조건실험 절차후처리출처 및 근거반응 노트

참가 물질

6

반응물 4

HCID 176Acetic AcidHCID 702EthanolHCID 14798Sodium HydroxideHCID 12137427(+/-)-7-(4-Ethoxycarbonyl-thiazol-2-yl)-8-methyl-5-(4-nitrophenyl)-8,9-dihydro-7H-1,3-dioxolo[4,5-h][2,3]benzodiazepine

생성물 1

HCID 22565444(+/-)-7-(4-Carboxythiazol-2-yl)-8-methyl-5-(4-nitrophenyl)-8,9-dihydro-7H-1,3-dioxolo[4,5-h][2,3]benzodiazepine수율 98%

시약·촉매·용매 1

HCID 962Water용매

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온도
90 °C

실험 절차

A mixture of 9 ml of ethanol, 0.85 g (1.89 mmol) of (±)-7-(4-ethoxycarbonyl-thiazol-2-yl)-8-methyl-5-(4-nitrophenyl)-8,9-dihydro-7H-1,3-dioxolo[4,5-h][2,3]benzodiazepine (Example 8) and 7 ml of 1N sodium hydroxide solution was stirred at 90° C. After cooling, it was acidified with acetic acid, diluted with water and the precipitated crystals were filtered off, washed with water and dried to yield 0.78 g (98%) of the title compound; Mp.: >260° C.

후처리

  1. temperatureAfter cooling
  2. filtrationthe precipitated crystals were filtered off
  3. washwashed with water
  4. customdried

출처 및 근거

ORD 기록
ord-4aac4ab194e646d7843ff9944d0c4efa
출처 데이터셋
uspto-grants-2005_02
DOI
10.6084/m9.figshare.5104873.v1
특허 번호
US06858605B2

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