Methanimidamide, N,N-diphenyl- → 2-(3-Methoxybenzoyl)-3-phenylamino-acrylonitrile

HRID 251357

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HRID 251357 반응식
[CH3:1][O:2][C:3]1[CH:4]=[C:5]([CH:11]=[CH:12][CH:13]=1)[C:6]([CH2:8][C:9]#[N:10])=[O:7].[C:14]1([N:20](C2C=CC=CC=2)[CH:21]=N)[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=1>C1(C)C=CC=CC=1>[CH3:1][O:2][C:3]1[CH:4]=[C:5]([CH:11]=[CH:12][CH:13]=1)[C:6]([C:8](=[CH:21][NH:20][C:14]1[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=1)[C:9]#[N:10])=[O:7]

참가 물질

4

반응물 2

HCID 78296Methanimidamide, N,N-diphenyl-HCID 5847163-(3-Methoxyphenyl)-3-oxopropanenitrile

생성물 1

HCID 670242862-(3-Methoxybenzoyl)-3-phenylamino-acrylonitrile

시약·촉매·용매 1

HCID 1140Toluene용매

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온도
100 °C

실험 절차

A solution of 3-methoxybenzoylacetonitrile (1.20 g, 68.5 mmol, 1.0 eq) and diphenylformamidine (1.34 g, 68.5 mmol, 1.0 eq) in 25 mL of toluene was stirred at room temperature for 2h then heated to 100° C. overnight. The solution was cooled and diluted with hexanes. The resulting solid was filtered and dried to provide the desired product. HPLC (4 minute 10-90 gradient) tR 3.05 min; MS m/z 279.2 [M+H]+.

후처리

  1. temperatureThe solution was cooled
  2. filtrationThe resulting solid was filtered
  3. customdried

출처 및 근거

ORD 기록
ord-6dd22fdfc3474aa3af65bf73b381ac40
출처 데이터셋
uspto-grants-2011_01
특허 번호
US07863314B2

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