Hydrochloric Acid → Pyrazino[1,2-a]indole-3-carboxylic acid hydrochloride

HRID 25160노트

반응식

HRID 25160 반응식
[CH:1]1[C:6]2=[CH:7][C:8]3[CH:9]=[CH:10][CH:11]=[CH:12][C:13]=3[N:5]2[CH:4]=[C:3]([C:14]([O:16]CC)=[O:15])[N:2]=1.[OH-].[K+].O.[ClH:22]>CCO>[ClH:22].[CH:1]1[C:6]2=[CH:7][C:8]3[CH:9]=[CH:10][CH:11]=[CH:12][C:13]=3[N:5]2[CH:4]=[C:3]([C:14]([OH:16])=[O:15])[N:2]=1

참가 물질

6

반응물 4

HCID 313Hydrochloric AcidHCID 962WaterHCID 14797Potassium HydroxideHCID 12132803Ethyl pyrazino[1,2-a]indole-3-carboxylate

생성물 1

HCID 69607038Pyrazino[1,2-a]indole-3-carboxylic acid hydrochloride수율 34%

시약·촉매·용매 1

HCID 702Ethanol용매

실험 절차

To a solution of ethyl pyrazino[1,2-a]indole-3-carboxylate (0.49 g, 2.0 mmol) in EtOH (30 mL) is added crushed potassium hydroxide (1.1 g, 20.0 mmol) followed by water (30 mL). The resulting dark colored solution is stirred at rt for 40 min and then neutralized with conc. HCl to pH ˜2. The acidic mixture is concentrated to dryness to afford pyrazino[1,2-a]indole-3-carboxylic acid hydrochloride. HRMS (FAB) calcd for C12H8N2O2+H 213.0664, found 213.0658.

후처리

  1. concentrationThe acidic mixture is concentrated to dryness

출처 및 근거

ORD 기록
ord-5b84bc6f76324c7bb22e155f3162326e
출처 데이터셋
uspto-grants-2005_02
특허 번호
US06858613B2

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