Lithium hydroxide, monohydrate → (2S)-2-[(tert-Butoxycarbonyl)amino]-8-oxononanoic acid

HRID 251721노트

반응식

HRID 251721 반응식
C[O:2][C:3](=[O:21])[C@@H:4]([NH:13][C:14]([O:16][C:17]([CH3:20])([CH3:19])[CH3:18])=[O:15])[CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][C:10](=[O:12])[CH3:11].O[Li].O>C1COCC1.O>[C:17]([O:16][C:14]([NH:13][C@@H:4]([CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][C:10](=[O:12])[CH3:11])[C:3]([OH:21])=[O:2])=[O:15])([CH3:20])([CH3:19])[CH3:18]

참가 물질

5

반응물 2

HCID 168937Lithium hydroxide, monohydrateHCID 86627947(2S)-2-[(tert-Butoxycarbonyl)amino]-8-oxononanoic acid methyl ester

생성물 1

HCID 86627946(2S)-2-[(tert-Butoxycarbonyl)amino]-8-oxononanoic acid

시약·촉매·용매 2

HCID 962Water용매HCID 8028Tetrahydrofuran용매

실험 절차

(2S)-2-[(tert-Butoxycarbonyl)amino]-8-oxononanoic acid methyl ester (1 eq.) was dissolved in a 1:1 mixture of THF and water at RT and LiOH hydrate (1.2 eq.) was added and the mixture was stirred for 30 min. The mixture was partitioned between 0.1M HCl and DCM, separated and the organic phase was washed with water, dried (Na2SO4) and concentrated under reduced pressure. The colourless oil A1 obtained was used in the next step without purification. MS (ES) C14H25NO5 requires: 287, found: 288 (M+H)+.

후처리

  1. customThe mixture was partitioned between 0.1M HCl and DCM
  2. customseparated
  3. washthe organic phase was washed with water
  4. dry with materialdried (Na2SO4)
  5. concentrationconcentrated under reduced pressure

출처 및 근거

ORD 기록
ord-b7e33ada867245faa4f57e92df6a4b96
출처 데이터셋
uspto-grants-2011_01
특허 번호
US07863294B2

반응 노트

불러오는 중…