p-Bromoacetophenone → 2-(4-Bromophenyl)quinoline

HRID 251760

반응식

HRID 251760 반응식
[CH3:1][C:2]([C:4]1[CH:9]=[CH:8][C:7]([Br:10])=[CH:6][CH:5]=1)=O.[NH2:11][C:12]1[CH:25]=[CH:24][CH:23]=[CH:22][C:13]=1[C:14](C1C=CC=CC=1)=O.[OH-].[Na+]>C(O)C>[Br:10][C:7]1[CH:8]=[CH:9][C:4]([C:2]2[CH:1]=[CH:14][C:13]3[C:12](=[CH:25][CH:24]=[CH:23][CH:22]=3)[N:11]=2)=[CH:5][CH:6]=1

참가 물질

5

반응물 3

HCID 7466p-BromoacetophenoneHCID 14798Sodium HydroxideHCID 760802-Aminobenzophenone

생성물 1

HCID 14734442-(4-Bromophenyl)quinoline수율 78.3%

시약·촉매·용매 1

HCID 702Ethanol용매

실험 절차

Dissolving 5.0 g (25 mmol) of 4-bromoacetophenone and 5.0 g (25 mmol) of 2-aminobenzophenon into 50 milliliter of ethanol, adding 3.1 g of sodium hydroxide, the resultant suspension was refluxed under heating for 7 hours. After completion of the reaction, separation with filtration was carried out and resultant crystals were washed with water and ethanol, thereby obtaining 5.56 g of 2-(4-bromo-phenyl)-quinoline (yield: 61%).

후처리

  1. temperatureunder heating for 7 hours
  2. customAfter completion of the reaction, separation
  3. filtrationwith filtration
  4. washresultant crystals were washed with water and ethanol

출처 및 근거

ORD 기록
ord-c554a8b419c44fce967ba6f31283fd67
출처 데이터셋
uspto-grants-2011_01
특허 번호
US07867629B2

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