2-Aminopyridine → 2-(4-Iodophenyl)imidazo[1,2-a]pyridine
반응식
Br[CH2:2][C:3]([C:5]1[CH:10]=[CH:9][C:8]([I:11])=[CH:7][CH:6]=1)=O.[NH2:12][C:13]1[CH:18]=[CH:17][CH:16]=[CH:15][N:14]=1.C(=O)([O-])O.[Na+]>C(O)C>[I:11][C:8]1[CH:9]=[CH:10][C:5]([C:3]2[N:12]=[C:13]3[CH:18]=[CH:17][CH:16]=[CH:15][N:14]3[CH:2]=2)=[CH:6][CH:7]=1참가 물질
5
실험 절차
Dissolving 27 g (83 mmol) of crude 2-bromo-4′-iodo acetophenone thus obtained and 8.0 g (85 mmol) of 2-aminopyridine into 200 milliliter of ethanol, adding 10 g of sodium hydrogen carbonate, the resultant suspension was refluxed under heating for 6 hours. After completion of the reaction, separation with filtration was carried out and resultant crystals were washed with water and ethanol, thereby obtaining 21 g of 2-(4-iodophenyl)-imidazo [1,2-a] pyridine (yield: 82%).
후처리
- customthus obtained
- temperatureunder heating for 6 hours
- customAfter completion of the reaction, separation
- filtrationwith filtration
- washresultant crystals were washed with water and ethanol
출처 및 근거
- ORD 기록
- ord-17ed4fda02294e4a9abd48b72f4472a6
- 출처 데이터셋
- uspto-grants-2011_01
- 특허 번호
- US07867629B2
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