1,2-Dichloroethane → 1-(4'-Bromo(1,1'-biphenyl)-4-yl)ethan-1-one

HRID 251770

반응식

HRID 251770 반응식
[Cl-].[Al+3].[Cl-].[Cl-].ClCCCl.[C:9](Cl)(=[O:11])[CH3:10].[Br:13][C:14]1[CH:19]=[CH:18][C:17]([C:20]2[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=2)=[CH:16][CH:15]=1>O>[Br:13][C:14]1[CH:15]=[CH:16][C:17]([C:20]2[CH:25]=[CH:24][C:23]([C:9](=[O:11])[CH3:10])=[CH:22][CH:21]=2)=[CH:18][CH:19]=1

참가 물질

6

반응물 4

HCID 111,2-Dichloroethane2회HCID 6367Acetyl chlorideHCID 71014-BromobiphenylHCID 6451240Aluminum(III) Chloride

생성물 1

HCID 798061-(4'-Bromo(1,1'-biphenyl)-4-yl)ethan-1-one수율 102.1%

시약·촉매·용매 1

HCID 962Water용매

실험 절차

Four point three grams (32 mmol) of aluminum chloride was placed into 30 milliliter of 1,2-dichloroethane and a solution made by dissolving 2.0 g (25 mmol) of acetyl chloride, subsequently 5.0 g (21 mmol) of 4-bromo biphenyl into 20 milliliter of 1,2-dichloroethane was added while cooling with ice. The mixed solution was stirred as it is while cooling with ice for 4 hours. After completion of the reaction, adding water and an extraction was carried out using dichloro-methane. Further, washing with water, dried with the use of sodium sulfate. Removing the solvent by distillation, 5.9 g of crude 1-(4′-bromo-biphenyl-4-yl)-ethanone was obtained.

후처리

  1. additionwas added
  2. temperaturewhile cooling with ice
  3. temperaturewhile cooling with ice for 4 hours
  4. customAfter completion of the reaction
  5. extractionan extraction
  6. washFurther, washing with water
  7. dry with materialdried with the use of sodium sulfate
  8. customRemoving the solvent
  9. distillationby distillation

출처 및 근거

ORD 기록
ord-77e2e9fe06a04dd18e6c45b442fccbf2
출처 데이터셋
uspto-grants-2011_01
특허 번호
US07867629B2

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