Water → 3-(2-Bromoacetyl)benzonitrile
반응식
[Br:1]Br.[C:3]([C:6]1[CH:7]=[C:8]([CH:11]=[CH:12][CH:13]=1)[C:9]#[N:10])(=[O:5])[CH3:4].O>CCOCC>[Br:1][CH2:4][C:3]([C:6]1[CH:7]=[C:8]([CH:11]=[CH:12][CH:13]=1)[C:9]#[N:10])=[O:5]참가 물질
5
실험 절차
Br2 (1 mmol) was dropwise added to a solution of 3-acetylbenzonitrile (1 mmol) in Et2O (15 ml) at 0° C., and then the mixture was stirred at r.t. for 4 h. Water was added, and the mixture was extracted with EtOAc. The organic layer was dried over Na2SO4, and was concentrated to give an oil, i.e., 3-(2-bromoacetyl)benzonitrile, which was directly used for the next step without purification.
후처리
- extractionthe mixture was extracted with EtOAc
- dry with materialThe organic layer was dried over Na2SO4
- concentrationwas concentrated
출처 및 근거
- ORD 기록
- ord-bc195a55eb7041ccb0c4ce7b56ac6d09
- 출처 데이터셋
- uspto-grants-2011_01
- 특허 번호
- US07868001B2
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