Water → 3-(2-Bromoacetyl)benzonitrile

HRID 251821

반응식

HRID 251821 반응식
[Br:1]Br.[C:3]([C:6]1[CH:7]=[C:8]([CH:11]=[CH:12][CH:13]=1)[C:9]#[N:10])(=[O:5])[CH3:4].O>CCOCC>[Br:1][CH2:4][C:3]([C:6]1[CH:7]=[C:8]([CH:11]=[CH:12][CH:13]=1)[C:9]#[N:10])=[O:5]

참가 물질

5

반응물 3

HCID 962WaterHCID 24408BromineHCID 802223-Acetylbenzonitrile

생성물 1

HCID 27358673-(2-Bromoacetyl)benzonitrile

시약·촉매·용매 1

HCID 3283Diethyl Ether용매

실험 절차

Br2 (1 mmol) was dropwise added to a solution of 3-acetylbenzonitrile (1 mmol) in Et2O (15 ml) at 0° C., and then the mixture was stirred at r.t. for 4 h. Water was added, and the mixture was extracted with EtOAc. The organic layer was dried over Na2SO4, and was concentrated to give an oil, i.e., 3-(2-bromoacetyl)benzonitrile, which was directly used for the next step without purification.

후처리

  1. extractionthe mixture was extracted with EtOAc
  2. dry with materialThe organic layer was dried over Na2SO4
  3. concentrationwas concentrated

출처 및 근거

ORD 기록
ord-bc195a55eb7041ccb0c4ce7b56ac6d09
출처 데이터셋
uspto-grants-2011_01
특허 번호
US07868001B2

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