Isocyanatocyclopropane → HCID 66861132, 화합물

HRID 251865

반응식

HRID 251865 반응식
[CH:1]1([N:4]=[C:5]=[O:6])[CH2:3][CH2:2]1.[CH:7]1([N:10]2[C:19]3[C:14](=[CH:15][C:16]([F:30])=[C:17]([N:22]4[CH2:27][CH:26]([CH3:28])[NH:25][CH:24]([CH3:29])[CH2:23]4)[C:18]=3[O:20][CH3:21])[C:13](=[O:31])[C:12]([C:32]([NH:34][CH2:35][C:36]3[CH:41]=[CH:40][C:39]([Cl:42])=[CH:38][C:37]=3[Cl:43])=[O:33])=[CH:11]2)[CH2:9][CH2:8]1>ClCCl>[CH:7]1([N:10]2[C:19]3[C:14](=[CH:15][C:16]([F:30])=[C:17]([N:22]4[CH2:23][CH:24]([CH3:29])[N:25]([C:5]([NH:4][CH:1]5[CH2:3][CH2:2]5)=[O:6])[CH:26]([CH3:28])[CH2:27]4)[C:18]=3[O:20][CH3:21])[C:13](=[O:31])[C:12]([C:32]([NH:34][CH2:35][C:36]3[CH:41]=[CH:40][C:39]([Cl:42])=[CH:38][C:37]=3[Cl:43])=[O:33])=[CH:11]2)[CH2:9][CH2:8]1

참가 물질

4

반응물 2

HCID 637659IsocyanatocyclopropaneHCID 668599621-Cyclopropyl-N-(2,4-dichlorobenzyl)-7-[(3RS,5SR)-3,5-dimethylpiperazin-1-yl]-6-fluoro-8-methoxy-4-oxo-1,4-dihydroquinoline-3-carboxamide

생성물 1

HCID 66861132HCID 66861132, 화합물

시약·촉매·용매 1

HCID 6344Dichloromethane용매

실험 절차

30 μl (24.3 mg, 0.29 mmol) of cyclopropylisocyanate are dissolved in dichloromethan, 80.0 mg (0.146 mmol) of the compound of Example 12 are added and the mixture is stirred over night at room temperature. For the work-up the solvent is removed completely and after fine purification by preparative RP-HPLC (Method 6) 55 mg of the target compound are obtained.

후처리

  1. customFor the work-up the solvent is removed completely
  2. customafter fine purification by preparative RP-HPLC (Method 6) 55 mg of the target compound
  3. customare obtained

출처 및 근거

ORD 기록
ord-d9c6184ee2354d53a2328dc7ba903420
출처 데이터셋
uspto-grants-2011_01
특허 번호
US07867992B2

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