Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Isocyanatocyclopropane → HCID 66861132, 화합물
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Isocyanatocyclopropane | HCID 637659 | — |
| 반응물 | 1-Cyclopropyl-N-(2,4-dichlorobenzyl)-7-[(3RS,5SR)-3,5-dimethylpiperazin-1-yl]-6-fluoro-8-methoxy-4-oxo-1,4-dihydroquinoline-3-carboxamide | HCID 66859962 | — |
| 용매 | Dichloromethane | HCID 6344 | — |
| 생성물 | HCID 66861132 | HCID 66861132 | — |
반응 단계
30 μl (24.3 mg, 0.29 mmol) of cyclopropylisocyanate are dissolved in dichloromethan, 80.0 mg (0.146 mmol) of the compound of Example 12 are added and the mixture is stirred over night at room temperature. For the work-up the solvent is removed completely and after fine purification by preparative RP-HPLC (Method 6) 55 mg of the target compound are obtained.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US07867992B2 |
| 출처 데이터셋 | uspto-grants-2011_01 |
| ORD ID | ord-d9c6184ee2354d53a2328dc7ba903420 |
| 출처 메모 | uspto-grants-2011_01 |