Pyrazole → N,N-dimethyl-1H-pyrazole-1-sulfonamide

HRID 251912

반응식

HRID 251912 반응식
[NH:1]1[CH:5]=[CH:4][CH:3]=[N:2]1.C1(C)C=CC=CC=1.[CH3:13][N:14]([CH3:19])[S:15](Cl)(=[O:17])=[O:16]>C(N(CC)CC)C>[CH3:13][N:14]([CH3:19])[S:15]([N:1]1[CH:5]=[CH:4][CH:3]=[N:2]1)(=[O:17])=[O:16]

참가 물질

5

반응물 3

HCID 1048PyrazoleHCID 1140TolueneHCID 83372Dimethylsulphamoyl chloride

생성물 1

HCID 10954038N,N-dimethyl-1H-pyrazole-1-sulfonamide

시약·촉매·용매 1

HCID 8471Triethylamine용매

실험 절차

To a mixture of 15 g of pyrazole and 200 ml of toluene was added dropwise 23.7 ml of dimethylsulfamoyl chloride at room temperature. Then, 40 ml of triethylamine was added to the mixture, and the mixture was stirred at room temperature for 18 hours. The reaction mixture was filtered, and the filtrate was concentrated under reduced pressure. The resulting residue was subjected to silica gel column chromatography to obtain 17.6 g of N,N-dimethyl-1H-pyrazole-1-sulfonamide of the formula:

후처리

  1. filtrationThe reaction mixture was filtered
  2. concentrationthe filtrate was concentrated under reduced pressure

출처 및 근거

ORD 기록
ord-14e014218f524dfa98603c57aeceaf44
출처 데이터셋
uspto-grants-2011_01
특허 번호
US07867949B2

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