Pyridinium chloride → Benzo(b)thiophene-6-ol
반응식
C[O:2][C:3]1[CH:4]=[CH:5][C:6]2[CH:10]=[CH:9][S:8][C:7]=2[CH:11]=1.Cl.N1C=CC=CC=1>O>[S:8]1[CH:9]=[CH:10][C:6]2[CH:5]=[CH:4][C:3]([OH:2])=[CH:11][C:7]1=2참가 물질
4
반응 조건
- 온도
- 100 °C
실험 절차
6-Methoxybenzo[b]thiophene (6.15 g, 37.45 mmol) and pyridine hydrochloride (18.5 g) were heated together at 210° C. for 1 h. The mixture was cooled to 100° C., diluted with water (125 mL) and extracted with dichloromethane (3×70 mL). The combined extracts were washed with water (125 mL), dried (MgSO4) and evaporated in vacuo to give the title compound (5.54 g, 98%)
후처리
- extractionextracted with dichloromethane (3×70 mL)
- washThe combined extracts were washed with water (125 mL)
- dry with materialdried (MgSO4)
- customevaporated in vacuo
출처 및 근거
- ORD 기록
- ord-5e1e09f2b3994491a6902c43b3fe3a66
- 출처 데이터셋
- uspto-grants-2011_01
- 특허 번호
- US07868017B2
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