Pyridine → HCID 58230872, 화합물

HRID 252236

반응식

HRID 252236 반응식
[NH2:1][C:2]1[CH:10]=[CH:9][C:5]([C:6]([OH:8])=[O:7])=[CH:4][C:3]=1[OH:11].N1C=CC=CC=1.[Cl:18][C:19]1[CH:27]=[CH:26][C:22]([C:23](Cl)=[O:24])=[CH:21][N:20]=1>C1COCC1>[Cl:18][C:19]1[N:20]=[CH:21][C:22]([C:23]([NH:1][C:2]2[CH:10]=[CH:9][C:5]([C:6]([OH:8])=[O:7])=[CH:4][C:3]=2[OH:11])=[O:24])=[CH:26][CH:27]=1

참가 물질

5

반응물 3

HCID 1049PyridineHCID 1375664-Amino-3-hydroxybenzoic acidHCID 27821656-Chloronicotinoyl Chloride

생성물 1

HCID 58230872HCID 58230872, 화합물수율 85.4%

시약·촉매·용매 1

HCID 8028Tetrahydrofuran용매

실험 절차

To a stirred solution of 4-Amino-3-hydroxy benzoic acid (0.490 g, 0.0032 mols) and pyridine (0.76 g, 0.0096 mols) in 50 ml dry THF is added 6-chloronicotinoyl chloride (0.56 g, 0.0032 mols) and the solution is stirred under nitrogen atmosphere at RT for 10 hrs and then refluxed for 3 hrs. The reaction mixture is rotary evaporated and the residue is slurried in water and filtered to get the amide (0.8 g) which is taken for the next step without further purification.

후처리

  1. temperaturerefluxed for 3 hrs
  2. customThe reaction mixture is rotary evaporated
  3. filtrationfiltered

출처 및 근거

ORD 기록
ord-ea3d1a1b1e4f451592198345544bf6c8
출처 데이터셋
uspto-grants-2011_01
특허 번호
US07868033B2

연결된 노트

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