Potassium Carbonate → 1-(2-Amino-3-nitrophenoxy)-2,3-epoxypropane

HRID 25236

반응식

HRID 25236 반응식
S(C1C=CC(C)=CC=1)(O[CH2:5][CH:6]1[O:8][CH2:7]1)(=O)=O.[NH2:16][C:17]1[C:22]([N+:23]([O-:25])=[O:24])=[CH:21][CH:20]=[CH:19][C:18]=1[OH:26].C([O-])([O-])=O.[K+].[K+]>CC(C)=O>[NH2:16][C:17]1[C:22]([N+:23]([O-:25])=[O:24])=[CH:21][CH:20]=[CH:19][C:18]=1[O:26][CH2:5][CH:6]1[O:8][CH2:7]1

참가 물질

5

반응물 3

HCID 11430Potassium CarbonateHCID 160868Glycidyl tosylateHCID 41154952-Amino-3-Nitrophenol

생성물 1

HCID 113448381-(2-Amino-3-nitrophenoxy)-2,3-epoxypropane

시약·촉매·용매 1

HCID 180Acetone용매

실험 절차

21.7 g (0.095 mol) of glycidyl tosylate, 10 g (0.0475 mol) of 2-amino-3-nitrophenol and 6.5 g of crushed K2CO3 are mixed in acetone and the mixture is heated at reflux for 18 hours. The mixture is filtered and the solvent is evaporated under reduced pressure. The crude reaction product is purified by flash chromatography, elution being carried out with a 9/1 hexane/ethyl acetate mixture. The title compound is obtained. M.p.: 7°-78° C.

후처리

  1. temperaturethe mixture is heated
  2. temperatureat reflux for 18 hours
  3. filtrationThe mixture is filtered
  4. customthe solvent is evaporated under reduced pressure
  5. customThe crude reaction product
  6. customis purified by flash chromatography, elution

출처 및 근거

ORD 기록
ord-e07988679b094e7aa963e37ef2a90aed
출처 데이터셋
uspto-grants-2005_02
특허 번호
US06858629B1

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