Chloroacetaldehyde → 6-Bromoimidazo[1,2-a]pyrimidine

HRID 252361노트

반응식

HRID 252361 반응식
[Br:1][C:2]1[CH:3]=[N:4][C:5]([NH2:8])=[N:6][CH:7]=1.Cl[CH2:10][CH:11]=O>C(=O)([O-])O.[Na+]>[Br:1][C:2]1[CH:3]=[N:4][C:5]2[N:6]([CH:10]=[CH:11][N:8]=2)[CH:7]=1

참가 물질

4

반응물 2

HCID 33ChloroacetaldehydeHCID 2313102-Amino-5-bromopyrimidine

생성물 1

HCID 269676226-Bromoimidazo[1,2-a]pyrimidine

시약·촉매·용매 1

HCID 516892Sodium Bicarbonate용매

반응 조건

온도
25 °C

실험 절차

50 mmol of 5-bromo-pyrimidin-2-ylamine are dissolved in 200 ml of saturated aqueous sodium hydrogencarbonate solution. 55 mmol of chloroacetaldehyde are added to the reaction mixture and the mixture is stirred for 24 hours at 25° C. The mixture is extracted with ethyl acetate (3×300 ml) and the combined extracts are dried over sodium sulphate and evaporated under reduced pressure. Flash chromatography (SiO2 60F) of the residue provides the title compound which is identified on the basis of its Rf-value.

후처리

  1. extractionThe mixture is extracted with ethyl acetate (3×300 ml)
  2. dry with materialthe combined extracts are dried over sodium sulphate
  3. customevaporated under reduced pressure

출처 및 근거

ORD 기록
ord-de52d2604dca48af89272bdaf45e2e80
출처 데이터셋
uspto-grants-2011_01
특허 번호
US07868036B2

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