Hydrochloric Acid → 3,3,3-Trifluoro-2-(trifluoromethyl)-1,2-propanediol

HRID 252691

반응식

HRID 252691 반응식
B.[Na].O.[OH:4][C:5]([C:14]([F:17])([F:16])[F:15])([C:10]([F:13])([F:12])[F:11])[C:6](OC)=[O:7].Cl>C(OCC)C>[F:11][C:10]([F:12])([F:13])[C:5]([C:14]([F:15])([F:17])[F:16])([OH:4])[CH2:6][OH:7]

참가 물질

6

반응물 4

HCID 313Hydrochloric AcidHCID 962WaterHCID 9877912Methyl 3,3,3-trifluoro-2-hydroxy-2-trifluoromethylpropionateHCID 178418435HCID 178418435, 화합물

생성물 1

HCID 118056773,3,3-Trifluoro-2-(trifluoromethyl)-1,2-propanediol수율 96%

시약·촉매·용매 1

HCID 3283Diethyl Ether용매

실험 절차

To a mixture of 25.0 g of sodium boron hydride, 500 g of water, and 500 g of diethyl ether, with stirring, 100 g of methyl 2-hydroxy-3,3,3-trifluoro-2-trifluoromethylpropionate was added dropwise. The mixture was stirred for 10 hours, after which hydrochloric acid was added to quench the reaction. An organic layer was separated from the reaction mixture, concentrated, and distilled, obtaining 83.9 g of 3,3,3-trifluoro-2-trifluoromethyl-1,2-propane diol (yield 96%).

후처리

  1. stirringThe mixture was stirred for 10 hours
  2. customto quench
  3. customthe reaction
  4. customAn organic layer was separated from the reaction mixture
  5. concentrationconcentrated
  6. distillationdistilled

출처 및 근거

ORD 기록
ord-cbe3052df8844e5e83630c10c2df9151
출처 데이터셋
uspto-grants-2011_01
특허 번호
US07868199B2

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