Acetone → 3-(3-Amino-4-nitrophenyl)-1-propanol
반응식
[NH2:1][C:2]1[CH:3]=[C:4]([CH2:11][CH2:12][CH:13]=[O:14])[CH:5]=[CH:6][C:7]=1[N+:8]([O-:10])=[O:9].[BH4-].[Na+].CC(C)=O>O1CCCC1.CC(O)C.C(OCC)(=O)C>[NH2:1][C:2]1[CH:3]=[C:4]([CH2:11][CH2:12][CH2:13][OH:14])[CH:5]=[CH:6][C:7]=1[N+:8]([O-:10])=[O:9]참가 물질
7
반응 조건
- 온도
- -5 °C
실험 절차
A solution of aldehyde 80 (253 mg, 1.3 mmol) in tetrahydrofurane (1 mL) and propan-2-ol (2 mL) was treated with solid sodium borohydride (175 mg, 4.6 mmol) and stirred at −5° C. for 15 min. Acetone (5 mL) was added, stirred at the same temperature for 10 min and then diluted with ethyl acetate (100 mL), washed with 5% KHSO4 in water, then saturated NaHCO3 and finally with water, dried (MgSO4), and used for the next step without further purification.
후처리
- stirringstirred at the same temperature for 10 min
- washwashed with 5% KHSO4 in water
- dry with materialsaturated NaHCO3 and finally with water, dried (MgSO4)
- customused for the next step without further purification
출처 및 근거
- ORD 기록
- ord-17f881df57cc4512903ea2049bcbe2ff
- 출처 데이터셋
- uspto-grants-2011_01
- 특허 번호
- US07868205B2
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