Ethyl 3,4-dihydro-2H-1,4-benzoxazine-2-carboxylate → Lithium benzomorpholine-2-carboxylate
반응식
O.[OH-].[Li+:3].[O:4]1[CH:9]([C:10]([O:12]CC)=[O:11])[CH2:8][NH:7][C:6]2[CH:15]=[CH:16][CH:17]=[CH:18][C:5]1=2>O.O1CCOCC1>[O:4]1[CH:9]([C:10]([O-:12])=[O:11])[CH2:8][NH:7][C:6]2[CH:15]=[CH:16][CH:17]=[CH:18][C:5]1=2.[Li+:3]참가 물질
5
반응 조건
- 온도
- 25 °C
실험 절차
A solution of lithium hydroxide monohydrate (1.43 g, 34.2 mmol) in water (50 mL) was added to a solution of ethyl 3,4-dihydro-2H-benzo[b][1,4]oxazine-2-carboxylate (3.55 g, 17.1 mmol) in dioxane (50 mL), and the mixture was stirred at 25° C. for 21 h. The reaction mixture was concentrated to afford the title compound. MS m/z: 180 (M+1 of acid).
후처리
- concentrationThe reaction mixture was concentrated
출처 및 근거
- ORD 기록
- ord-638921f9b32b42dea4acc22d5e5b8562
- 출처 데이터셋
- uspto-grants-2011_01
- 특허 번호
- US07872009B2
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