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Hydrochloric Acid → 3-[2-(3',4'-dimethylbiphenyl-3-yl)-9-hydroxy-3H-naphtho[1,2-d]imidazole-7-sulfonylamino]-benzoic Acid

HRID 25320
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인쇄 미리보기

반응식

HRID 25320 반응식
[NH2:1][C:2]1[CH:3]=[C:4]([CH:8]=[CH:9][CH:10]=1)[C:5]([OH:7])=[O:6].[CH3:11][C:12]1[CH:13]=[C:14]([C:19]2[CH:24]=[CH:23][CH:22]=[C:21]([C:25]3[NH:26][C:27]4[CH:37]=[CH:36][C:35]5[C:30](=[C:31]([OH:42])[CH:32]=[C:33]([S:38](Cl)(=[O:40])=[O:39])[CH:34]=5)[C:28]=4[N:29]=3)[CH:20]=2)[CH:15]=[CH:16][C:17]=1[CH3:18].Cl>C1COCC1.O>[CH3:11][C:12]1[CH:13]=[C:14]([C:19]2[CH:24]=[CH:23][CH:22]=[C:21]([C:25]3[NH:26][C:27]4[CH:37]=[CH:36][C:35]5[C:30](=[C:31]([OH:42])[CH:32]=[C:33]([S:38]([NH:1][C:2]6[CH:3]=[C:4]([CH:8]=[CH:9][CH:10]=6)[C:5]([OH:7])=[O:6])(=[O:40])=[O:39])[CH:34]=5)[C:28]=4[N:29]=3)[CH:20]=2)[CH:15]=[CH:16][C:17]=1[CH3:18]
참가 물질실험 절차후처리출처 및 근거반응 노트

참가 물질

6

반응물 3

HCID 313Hydrochloric AcidHCID 74193-Aminobenzoic AcidHCID 225666742-(3',4'-dimethylbiphenyl-3-yl)-9-hydroxyl-3H-naphtho[1,2-d]imidazole-7-sulfonyl chloride

생성물 1

HCID 225665783-[2-(3',4'-dimethylbiphenyl-3-yl)-9-hydroxy-3H-naphtho[1,2-d]imidazole-7-sulfonylamino]-benzoic Acid수율 4.9%

시약·촉매·용매 2

HCID 962
Water
용매
HCID 8028Tetrahydrofuran용매

실험 절차

To an agitated suspension of 3-aminobenzoic acid (0.028 g, 0.2 mmol) in THF (1 mL) was added 2-(3′,4′-dimethylbiphenyl-3-yl)-9-hydroxyl-3H-naphtho[1,2-d]imidazole-7-sulfonyl chloride (0.083 g, 0.18 mmol) and sodium hydroxy (0.018 g, 0.4 mmol) in water (0.5 mL). After agitated for 30 minutes, the reaction mixture was added 6N hydrochloride (2 ml) and concentrated under reduced pressure. The residue was subjected to HPLC (ODS-A, gradient 10-90% CH3CN/water 0.1% TFA) to provide the title compound (0.005 g, 4%) MS(ES) m/z 564 [M+H].

후처리

  1. concentrationconcentrated under reduced pressure

출처 및 근거

ORD 기록
ord-2a5c08e5f3444db3941ed7195666aea4
출처 데이터셋
uspto-grants-2005_02
DOI
10.6084/m9.figshare.5104873.v1
특허 번호
US06858630B2

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