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Sodium Hydroxide → 4'-(3-Cyclopropylaminopropoxy)-3'-(5,5,8,8-tetramethyl-5,6,7,8-tetrahydronaphth-2-yl)biphenyl-4-carboxylic acid

HRID 253488
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HRID 253488 반응식
[OH-].[Na+].[CH:3]1([NH:6][CH2:7][CH2:8][CH2:9][O:10][C:11]2[CH:16]=[CH:15][C:14]([C:17]3[CH:22]=[CH:21][C:20]([C:23]([O:25]CC)=[O:24])=[CH:19][CH:18]=3)=[CH:13][C:12]=2[C:28]2[CH:37]=[CH:36][C:35]3[C:34]([CH3:39])([CH3:38])[CH2:33][CH2:32][C:31]([CH3:41])([CH3:40])[C:30]=3[CH:29]=2)[CH2:5][CH2:4]1>O1CCCC1>[CH:3]1([NH:6][CH2:7][CH2:8][CH2:9][O:10][C:11]2[CH:16]=[CH:15][C:14]([C:17]3[CH:22]=[CH:21][C:20]([C:23]([OH:25])=[O:24])=[CH:19][CH:18]=3)=[CH:13][C:12]=2[C:28]2[CH:37]=[CH:36][C:35]3[C:34]([CH3:39])([CH3:38])[CH2:33][CH2:32][C:31]([CH3:41])([CH3:40])[C:30]=3[CH:29]=2)[CH2:5][CH2:4]1
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참가 물질

4

반응물 2

HCID 14798Sodium HydroxideHCID 11398367Ethyl 4'-(3-cyclopropylaminopropoxy)-3'-(5,5,8,8-tetramethyl-5,6,7,8-tetrahydronaphth-2-yl)biphenyl-4-carboxylate

생성물 1

HCID 111679044'-(3-Cyclopropylaminopropoxy)-3'-(5,5,8,8-tetramethyl-5,6,7,8-tetrahydronaphth-2-yl)biphenyl-4-carboxylic acid수율 49.5%

시약·촉매·용매 1

HCID 8028Tetrahydrofuran용매

실험 절차

In a manner similar to that of Example 2a, by reaction of 260 mg (6.5 mmol) of sodium hydroxide with 340 mg (0.65 mmol) of ethyl 4′-(3-cyclopropylaminopropoxy)-3′-(5,5,8,8-tetramethyl-5,6,7,8-tetrahydronaphth-2-yl)biphenyl-4-carboxylate (Example 3a) in 30 ml of tetrahydrofuran. 160 mg of 4′-(3-cyclopropylaminopropoxy)-3′-(5,5,8,8-tetramethyl-5,6,7,8-tetrahydronaphth-2-yl)biphenyl-4-carboxylic acid are obtained in the form of a white solid (m.p.=192° C., yield=50%).

출처 및 근거

ORD 기록
ord-17fe6e1cbdec496cbf68c005abdf18c5
출처 데이터셋
uspto-grants-2011_01
DOI
10.6084/m9.figshare.5104873.v1
특허 번호
US07872026B2

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