Sertraline → Sertraline Hydrochloride

HRID 25351

반응식

HRID 25351 반응식
[CH3:1][NH:2][C@@H:3]1[C:8]2[CH:9]=[CH:10][CH:11]=[CH:12][C:7]=2[C@H:6]([C:13]2[CH:14]=[CH:15][C:16]([Cl:20])=[C:17]([Cl:19])[CH:18]=2)[CH2:5][CH2:4]1>C1(C)C=CC=CC=1>[CH3:1][NH:2][C@@H:3]1[C:8]2[CH:9]=[CH:10][CH:11]=[CH:12][C:7]=2[C@H:6]([C:13]2[CH:14]=[CH:15][C:16]([Cl:20])=[C:17]([Cl:19])[CH:18]=2)[CH2:5][CH2:4]1.[ClH:19]

참가 물질

3

반응물 1

HCID 68617Sertraline

생성물 1

HCID 63009Sertraline Hydrochloride

시약·촉매·용매 1

HCID 1140Toluene용매

실험 절차

Sertraline base (5.8 g) was dissolved in toluene (200 mL). Gaseous hydrochloric acid was bubbled (about pH 1.5) through the solution to induce the formation of sertraline hydrochloride Form XVI. The solution gelled while it was being acidified but remained stirrable. Filtration and drying at 50° C. for 16 hours yields sertraline hydrochloride Form XVI (6.61 gr.).

후처리

  1. customGaseous hydrochloric acid was bubbled (about pH 1.5) through the solution
  2. filtrationFiltration
  3. customdrying at 50° C. for 16 hours

출처 및 근거

ORD 기록
ord-9ee4cd5e050c42d7ab043c502bf67170
출처 데이터셋
uspto-grants-2005_02
특허 번호
US06858652B2

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