Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Sertraline → Sertraline Hydrochloride
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Sertraline | HCID 68617 | — |
| 용매 | Toluene | HCID 1140 | — |
| 생성물 | Sertraline Hydrochloride | HCID 63009 | — |
반응 단계
Sertraline base (5.8 g) was dissolved in toluene (200 mL). Gaseous hydrochloric acid was bubbled (about pH 1.5) through the solution to induce the formation of sertraline hydrochloride Form XVI. The solution gelled while it was being acidified but remained stirrable. Filtration and drying at 50° C. for 16 hours yields sertraline hydrochloride Form XVI (6.61 gr.).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US06858652B2 |
| 출처 데이터셋 | uspto-grants-2005_02 |
| ORD ID | ord-9ee4cd5e050c42d7ab043c502bf67170 |
| 출처 메모 | uspto-grants-2005_02 |