Trimethylsilyl iodide → HCID 178434306, 화합물

HRID 25365

반응식

HRID 25365 반응식
C(OC([N:8]1[C:16]2[C:11](=[CH:12][C:13]([NH:17][S:18]([C:21]3[CH:26]=[CH:25][CH:24]=[C:23]([F:27])[CH:22]=3)(=[O:20])=[O:19])=[CH:14][CH:15]=2)[C:10]([CH3:28])=[N:9]1)=O)(C)(C)C.I[Si](C)(C)C>C(Cl)(Cl)Cl>[F:27][C:23]1[CH:22]=[C:21]([S:18]([NH:17][C:13]2[CH:12]=[C:11]3[C:16](=[CH:15][CH:14]=2)[NH:8][N:9]=[C:10]3[CH3:28])(=[O:19])=[O:20])[CH:26]=[CH:25][CH:24]=1

참가 물질

4

반응물 2

HCID 85247Trimethylsilyl iodideHCID 22567075N-(N-tert-butoxycarbonyl-3-methyl-1H-indazol-5-yl)-3-fluorobenzenesulfonamide

생성물 1

HCID 178434306HCID 178434306, 화합물수율 59%

시약·촉매·용매 1

HCID 6212Chloroform용매

실험 절차

3-Fluoro-N-(3-methyl-1H-indazol-5-yl)benzenesulfonamide can be obtained as described in Example 6 from 1.35 g of N-(N-tert-butoxycarbonyl-3-methyl-1H-indazol-5-yl)-3-fluorobenzenesulfonamide, 13.5 ml of chloroform and 0.47 ml of iodotrimethylsilane. 0.6 g of 3-fluoro-N-(3-methyl-1H-indazol-5-yl)-benzenesulfonamide is thus obtained in the form of a white foam melting at 120° C. (analysis: C14H12FN3O2S.0.39CH2Cl2 % calculated, C, 55.07; H, 3.96; F, 6.22; N, 13.76; O, 10.48; S, 10.50. % found C, 54.99. H, 2.70; N, 13.81; S, 10.18).

출처 및 근거

ORD 기록
ord-8e23fa5fab5c4fe2acfd00d2ff12d90c
출처 데이터셋
uspto-grants-2005_02
특허 번호
US06858638B2

연결된 노트

불러오는 중…