Methyl iodide → 1-(1-Butyryl-piperidin-4-yl)-1-cyclohexyl-3-(5-methylsulfanyl-thiazol-2-yl)-urea

HRID 253811

반응식

HRID 253811 반응식
[C:1]([N:6]1[CH2:11][CH2:10][CH:9]([N:12]([CH:24]2[CH2:29][CH2:28][CH:27](C)[CH2:26][CH2:25]2)[C:13]([NH:15][C:16]2[S:17][C:18]([S:21][C:22]#N)=[CH:19][N:20]=2)=[O:14])[CH2:8][CH2:7]1)(=[O:5])[CH2:2][CH2:3][CH3:4].SC[C@@H]([C@@H](CS)O)O.CI>>[C:1]([N:6]1[CH2:7][CH2:8][CH:9]([N:12]([CH:24]2[CH2:25][CH2:26][CH2:27][CH2:28][CH2:29]2)[C:13]([NH:15][C:16]2[S:17][C:18]([S:21][CH3:22])=[CH:19][N:20]=2)=[O:14])[CH2:10][CH2:11]1)(=[O:5])[CH2:2][CH2:3][CH3:4]

참가 물질

4

반응물 3

HCID 6328Methyl iodideHCID 439352DithioerythritolHCID 866111891-(1-Butyryl-piperidin-4-yl)-1-(4-methyl-cyclohexyl)-3-(5-thiocyanato-thiazol-2-yl)-urea

생성물 1

HCID 578836551-(1-Butyryl-piperidin-4-yl)-1-cyclohexyl-3-(5-methylsulfanyl-thiazol-2-yl)-urea

실험 절차

Prepared as described in general procedure (H) and (I) using 1-(1-butyryl-piperidin-4-yl)-1-(4-methyl-cyclohexyl)-3-(5-thiocyanato-thiazol-2-yl)-urea, dithioerythritol and methyliodide.

후처리

  1. customPrepared

출처 및 근거

ORD 기록
ord-53ed6886296d45d1be24285f3568254a
출처 데이터셋
uspto-grants-2011_01
특허 번호
US07872139B2

연결된 노트

불러오는 중…