Hydrazine hydrate (1:1) → 5-Bromopyridine-2-carbohydrazide

HRID 254248

반응식

HRID 254248 반응식
C[O:2][C:3]([C:5]1[CH:10]=[CH:9][C:8]([Br:11])=[CH:7][N:6]=1)=O.O.[NH2:13][NH2:14]>CO>[Br:11][C:8]1[CH:9]=[CH:10][C:5]([C:3]([NH:13][NH2:14])=[O:2])=[N:6][CH:7]=1

참가 물질

4

반응물 2

HCID 24654Hydrazine hydrate (1:1)HCID 7016458Methyl 5-bromopyridine-2-carboxylate2회

생성물 1

HCID 234679385-Bromopyridine-2-carbohydrazide

시약·촉매·용매 1

HCID 887Methanol용매

실험 절차

5-Bromo-pyridine-2-carboxylic acid methyl ester (J. Org. Chem., 2001, 66(2), 605-608, compound 4) (18.10 g, 83 mmol) and hydrazine monohydrate (12.5 mL, 250 mmol) were dissolved in methanol (400 mL) and the reaction mixture heated to reflux for 48 hours. The reaction mixture was then filtered and the precipitate collected dried in vacuo to yield the title product, 15.40 g.

후처리

  1. temperaturethe reaction mixture heated
  2. temperatureto reflux for 48 hours
  3. filtrationThe reaction mixture was then filtered
  4. customthe precipitate collected
  5. customdried in vacuo

출처 및 근거

ORD 기록
ord-cabaad21c61a4c72b741a6c4de69f450
출처 데이터셋
uspto-grants-2011_01
특허 번호
US07875615B2

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