Acetonitrile → HCID 23135106, 화합물

HRID 254277

반응식

HRID 254277 반응식
Br[CH2:2][CH2:3][CH2:4][CH2:5][NH:6][C:7]([CH:9]1[CH:18]=[CH:17][C:16]2[C:11](=[CH:12][CH:13]=[CH:14][CH:15]=2)[CH2:10]1)=[O:8].[OH:19][C:20]1[CH:21]=[C:22](N2CCNCC2)[CH:23]=[CH:24][CH:25]=1.C([N:34]([CH2:37][CH3:38])[CH2:35][CH3:36])C.CC#[N:41]>>[OH:19][C:20]1[CH:21]=[C:22]([CH:35]2[CH2:36][NH:41][CH2:38][CH2:37][N:34]2[CH2:2][CH2:3][CH2:4][CH2:5][NH:6][C:7]([C:9]2[CH2:18][CH2:17][C:16]3[C:11](=[CH:12][CH:13]=[CH:14][CH:15]=3)[CH:10]=2)=[O:8])[CH:23]=[CH:24][CH:25]=1

참가 물질

5

반응물 4

HCID 6342AcetonitrileHCID 8471TriethylamineHCID 27365971-(3-Hydroxyphenyl)piperazineHCID 66852491HCID 66852491, 화합물

생성물 1

HCID 23135106HCID 23135106, 화합물수율 54%

실험 절차

A mixture of the bromo adduct E1 (100 mg, 0.32 mmol), of commercial 3-hydroxyphenyl piperazine (57 mg, 0.32 mmol) and triethylamine (0.07 mL, 0.5 mmol) in CH3CN are reluxed during 16 h. The solvent is evaporated and the residue is taken up in CH2Cl2 (15 mL), washed with brine, dried and concentrated. The residue is purified by chromatography eluting with AcOEt:MeOH (9/1) to yield the titled adduct (mp 152° C., 70 mg, 54%)

후처리

  1. customThe solvent is evaporated
  2. washwashed with brine
  3. customdried
  4. concentrationconcentrated
  5. customThe residue is purified by chromatography
  6. washeluting with AcOEt

출처 및 근거

ORD 기록
ord-d5c811394752484d9f35c8383a6030e7
출처 데이터셋
uspto-grants-2011_01
특허 번호
US07875617B2

연결된 노트

불러오는 중…