Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Acetonitrile → HCID 23135106, 화합물
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Acetonitrile | HCID 6342 | — |
| 반응물 | Triethylamine | HCID 8471 | — |
| 반응물 | 1-(3-Hydroxyphenyl)piperazine | HCID 2736597 | — |
| 반응물 | HCID 66852491 | HCID 66852491 | — |
| 생성물 | HCID 23135106 | HCID 23135106 | 54% |
반응 단계
A mixture of the bromo adduct E1 (100 mg, 0.32 mmol), of commercial 3-hydroxyphenyl piperazine (57 mg, 0.32 mmol) and triethylamine (0.07 mL, 0.5 mmol) in CH3CN are reluxed during 16 h. The solvent is evaporated and the residue is taken up in CH2Cl2 (15 mL), washed with brine, dried and concentrated. The residue is purified by chromatography eluting with AcOEt:MeOH (9/1) to yield the titled adduct (mp 152° C., 70 mg, 54%)
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US07875617B2 |
| 출처 데이터셋 | uspto-grants-2011_01 |
| ORD ID | ord-d5c811394752484d9f35c8383a6030e7 |
| 출처 메모 | uspto-grants-2011_01 |