Ammonium formate → 4-Fluoro-2-(4-methyl-1H-imidazol-1-yl)aniline

HRID 254291

반응식

HRID 254291 반응식
[F:1][C:2]1[CH:3]=[CH:4][C:5]([N+:14]([O-])=O)=[C:6]([N:8]2[CH:12]=[C:11]([CH3:13])[N:10]=[CH:9]2)[CH:7]=1.C([O-])=O.[NH4+]>[Pd]>[F:1][C:2]1[CH:3]=[CH:4][C:5]([NH2:14])=[C:6]([N:8]2[CH:12]=[C:11]([CH3:13])[N:10]=[CH:9]2)[CH:7]=1

참가 물질

4

반응물 2

HCID 2723923Ammonium formateHCID 577324471-(5-Fluoro-2-nitrophenyl)-4-methyl-1H-imidazole

생성물 1

HCID 577324454-Fluoro-2-(4-methyl-1H-imidazol-1-yl)aniline수율 104.9%

시약·촉매·용매 1

HCID 23938Palladium촉매

실험 절차

Reaction of intermediate 1A (20.2 g, 91.4 mmol), 10% Pd/C (5.0 g, 4.57 mmol), and ammonium formate (34.7 g, 502.7 mmol) provided the product 2A as an off-white solid (18.34 g, 99% yield). EIMS 192.0 [M+H]+.

출처 및 근거

ORD 기록
ord-3b84d77112544adc8a0e93735b9ffb66
출처 데이터셋
uspto-grants-2011_01
특허 번호
US07875618B2

연결된 노트

불러오는 중…