Phosphorus oxide (P4O10) → 8-Fluoro-3,4-dimethylimidazo[1,5-a]quinoxaline

HRID 254293

반응식

HRID 254293 반응식
[F:1][C:2]1[CH:7]=[CH:6][C:5]([NH:8][C:9](=O)[CH3:10])=[C:4]([N:12]2[CH:16]=[C:15]([CH3:17])[N:14]=[CH:13]2)[CH:3]=1.O=P12OP3(OP(OP(O3)(O1)=O)(=O)O2)=O>O=P(Cl)(Cl)Cl>[F:1][C:2]1[CH:3]=[C:4]2[C:5]([N:8]=[C:9]([CH3:10])[C:16]3[N:12]2[CH:13]=[N:14][C:15]=3[CH3:17])=[CH:6][CH:7]=1

참가 물질

4

반응물 2

HCID 14812Phosphorus oxide (P4O10)HCID 57732446N-(4-Fluoro-2-(4-methyl-1H-imidazol-1-yl)phenyl)acetamide

생성물 1

HCID 577324598-Fluoro-3,4-dimethylimidazo[1,5-a]quinoxaline수율 22%

시약·촉매·용매 1

HCID 24813Phosphorus oxychloride용매

실험 절차

Reaction of intermediate 3A (13.4 g, 57.5 mmol), P2O5 (16.3 g, 115 mmol), and POCl3 (100 mL) provided the product 4A as an off-white powder (1.6 g, 22% yield). EIMS 216.1 [M+H]+.

출처 및 근거

ORD 기록
ord-1896b14a0fe3438f928d9aca39aae719
출처 데이터셋
uspto-grants-2011_01
특허 번호
US07875618B2

연결된 노트

불러오는 중…